Jiantao Guo

Assistant Professor
Assistant Professor Profile Image

Department of Chemistry
University of Nebraska-Lincoln
634AA Hamilton Hall
Lincoln, NE 68588-0304
(402) 472-3525


Postdoctoral, The Scripps Research Institute
Postdoctoral, Michigan State University
Ph.D., Michigan State University
M.S., Nankai University
B.S., Nankai University

Research Interests

Chemical biology, bioorganic chemistry, synthetic biology, biomolecular evolution

Current Research

Our lab is a place where chemistry meets biology. The main focus of the group is on the study, modulation, and synthesis of a range of biologically important molecules including proteins, natural products, and artificial molecules. We are particularly interested in the elucidation of molecular mechanisms that are used by living organisms to achieve essential chemical transformations and the utilization of principles and tools of chemistry to manipulate biological processes.

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Specific areas being explored include: (1) protein posttranslational modification (e.g., Protein tyrosine O-sulfation); (2) natural product biosynthesis; (3) small-molecule modulators of protein-protein interactions; and (4) chemo-biocatalytic syntheses. The goal of the research program is to use multidisciplinary and innovative approaches to tackle fundamental problems associated with human diseases and sustainable chemical production.

For more information, please visit the Guo Research Group Homepage.

Selected Publications

(1) Guo, J.; Melançon III, C. E.; Lee, H. S.; Groff, D.; Schultz, P. G. "Evolution of Amber Suppressor tRNAs for Efficient Bacterial Production of Unnatural Amino Acid-Containing Proteins" Angew. Chem. Int. Ed. Engl. 200948, 9148-9151. [Link]

(2) Guo, J.; Wang, J.; Anderson, J. C.; Schultz, P. G. “Addition of an a-Hydroxy Acid to the Genetic Code of Bacteria” Angew. Chem. Int. Ed. 200847, 722 –725. (This article was highlighted in Nature.) [Link]

(3) Guo, J.; Wang, J.; Lee, J. S.; Schultz, P. G. “Site-Specific Incorporation of Methyl- and Acetyl-Lysine Analogues into Recombinant Proteins” Angew. Chem. Int. Ed. 2008, 47, 6399–6401. (This article was highlighted in “Faculty of 1000 Biology”.) [Link]

Complete list of publications