I am working on a forensic science project in
partnership with Nebraska State Patrol Crime Lab
developing an explosives detection method based on
immunoextraction and capillary electrophoresis.
polymerization occurs in the presence of a
molecule of interest, the resulting polymer will
have an imprint of this molecule.When the imprint molecule is removed, a
binding site is created and the polymer will be
able to selectively rebind the molecule.Such polymers are known as molecularly
imprinted polymers (MIPs) and have been used in
affinity chromatography.I have been working on using them in
environmental separations, namely in studying
veterinary antibiotics in water.
My research is focused on the use of ultrafast immunoextraction/ displacement assay for determining free drug fractions. Another project I will be working on is the study of factors that affect the performance of displacement assays and model displacement assays for drugs and their metabolites.
Most research dealing with drug-protein interaction is preformed using protein that is immobilized onto a support. This immobilization may alter the protein's binding ability. Currently, I am working on a new method of entrapping protein inside a silica pore. This research will determine whether an entrapped protein binds to drugs differently than an immobilized protein.
My research focuses on drug-protein interactions using HSA as the protein of interest. There are few projects I will be working on. One is researching imipramine and HSA and testosterone and protein interactions. I hope to be working on silica monoliths as well in the future.