Postdoctoral, The Scripps Research Institute
Postdoctoral, Michigan State University
Ph.D. Michigan State University
M.S. Nankai University
B.S. Nankai University
Chemical Biology, Bioorganic Chemistry, Synthetic Biology,
Our lab is a place where chemistry meets biology. The main focus of the group is on the study, modulation, and synthesis of a range of biologically important molecules including proteins, natural products, and artificial molecules. We are particularly interested in the elucidation of molecular mechanisms that are used by living organisms to achieve essential chemical transformations and the utilization of principles and tools of chemistry to manipulate biological processes.
Specific areas being explored include: (1) protein posttranslational modification (e.g., Protein tyrosine O-sulfation); (2) natural product biosynthesis; (3) small-molecule modulators of protein-protein interactions; and (4) chemo-biocatalytic syntheses. The goal of the research program is to use multidisciplinary and innovative approaches to tackle fundamental problems associated with human diseases and sustainable chemical production.
For more information, please visit the Guo Research Group Homepage.
Guo, J.; Melançon III, C. E.; Lee, H. S.; Groff, D.; Schultz, P. G. "Evolution of Amber Suppressor tRNAs for Efficient Bacterial Production of Unnatural Amino Acid-Containing Proteins" Angew. Chem. Int. Ed. Engl. 2009, 48, 9148-9151. [Link]
Guo, J.; Wang, J.; Anderson, J. C.; Schultz, P. G. “Addition of an a-Hydroxy Acid to the Genetic Code of Bacteria” Angew. Chem. Int. Ed. 2008, 47, 722 –725. (This article was highlighted in Nature.) [Link]
Guo, J.; Wang, J.; Lee, J. S.; Schultz, P. G. “Site-Specific Incorporation of Methyl- and Acetyl-Lysine Analogues into Recombinant Proteins” Angew. Chem. Int. Ed. 2008, 47, 6399–6401. (This article was highlighted in “Faculty of 1000 Biology”.) [Link]
An undergraduate, graduate, or postdoctoral student in my group can expect to receive training in:
For more information, please visit the Guo Research Group website.
If you are seeking an exciting graduate career that helps you develop research skills at the interface of chemistry and biology, and are a self-motivated and creative individual, please email a letter of interest or resume to Prof. Guo at firstname.lastname@example.org.