Stephen G. DiMagno


Professor

Educational Background
Postdoctoral Research, University of Pennsylvania
Ph.D. University of California, Berkeley
B.A., Swarthmore College

Research Interests
Fuel cells, C-H activation, biofuel reforming, synthetic dehydrogenases, catalysis, fluorine chemistry, imaging agents


DiMagno Research Group
Current Research | Publications | Prospective Students


Stephen G. DiMagno
Hamilton Hall 818C
402.472.9895
sdimagno1@unl.edu

Current Research
Research in my laboratory provides tools for, and insights into two technologically important problems: energy conversion and drug design. Aqueous conversion of renewable fuel sources to hydrogen can be performed with transition metal and solid state catalysts. Such aqueous reforming generates hydrogen-rich fuel streams that are contaminated with carbon monoxide. We develop reforming catalysts that selectively oxidize CO, and fuel cell electrodes tolerant to CO.

fig1
Preferential CO oxidation by a water soluble rhodium complex. Addition of CO causes reduction of the blue dye, indigo carmine. Reoxidation by air regenerates the indicator.

Despite their rarity in nature, organofluorine compounds play a leading role in medicinal chemistry. The fluorine atom's high electronegativity and small atomic radius mean that incorporation of fluorine into biologically active compounds induces a relatively small structural perturbation, while drastically altering the compounds' electronic properties and bioavailability. Fluorine substitution is a particularly effective strategy for aromatic groups, since the electron-withdrawing nature of fluorine reduces and aryl ring's susceptibility to P-450 catalyzed oxidation, a key step in drug metabolism. We develop nucleophilic fluorinating agents to provide medicinal chemists with the tools necessary to carry out safe, rapid and efficient fluorinations.

fig2
An aromatic fluorodenitration reaction modeled by DFT methods.

For more information, please visit the DiMagno Research Group Homepage.



Selected Publications

A Convenient Alternative to Karl Fischer Titration. Sun, Haoran; Wang, Bijia; DiMagno, Stephen G.. Department of Chemistry, University of South Dakota, Vermillion, SD, USA. Abstracts, 43rd Midwest Regional Meeting of the American Chemical Society, Kearney, NE, United States, October 8-11 (2008), MWRM-170. Publisher: American Chemical Society, Washington, D. C Conference.

A method for detecting water in organic solvents. Sun, Haoran; Wang, Bijia; DiMagno, Stephen G.. Department of Chemistry, University of Nebraska, Lincoln, NE, USA. Organic Letters (2008), 10(20), 4413-4416. Publisher: American Chemical Society.

Optimization of Fluoride Relay. Sun, Haoran; Qin, Linlin; Wang, Bijia; DiMagno, Stephen G.. Department of Chemistry, University of South Dakota, Vermillion, SD, USA. Abstracts, 43rd Midwest Regional Meeting of the American Chemical Society, Kearney, NE, United States, October 8-11 (2008), MWRM-200. Publisher: American Chemical Society, Washington, D. C Conference.

Complete list of publications