Eric Dodds

Assistant Professor
Assistant Professor Profile Image

Department of Chemistry
University of Nebraska-Lincoln
711 Hamilton Hall
Lincoln, NE 68588-0304
(402) 472-3592
edodds2@unl.edu

Education

Postdoctoral, University of Arizona
Ph.D., University of California Davis
B.S., University of Alaska Anchorage

Research Interests

Analytical chemistry, biochemistry, mass spectrometry, ion mobility spectrometry

Current Research

Research activities in the Dodds laboratory are concentrated on the conception and implementation of mass spectrometry based strategies for the analysis of biomolecules. More specifically, the group is focused on the development of new capabilities for carbohydrate and glycoconjugate analysis, with particular emphasis on the site-specific determination of protein glycosylation and on the distinction of carbohydrate isomers. Additional areas of study include the structural interrogation of noncovalent biomolecular assemblies and the development of novel approaches for metabolomic analysis. In each of these fields, the group combines a unique body of expertise with leading-edge capabilities in mass spectrometry, tandem mass spectrometry, and ion mobility spectrometry to address longstanding bioanalytical challenges.

The primary research tool of the Dodds laboratory is a Waters Synapt G2-S HDMS. This instrument affords a powerful combination of analytical capabilities, including high resolution, accurate mass measurement over a wide mass range; tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation; and ion mobility based separation and collisional cross section measurement. In concert, these technologies allow our laboratory to address demanding questions in the bioanalytical, biochemical, and biomedical sciences, and to advance new mass spectrometry methodologies through study of gas-phase ion structures and dissociation processes as they relate to bioanalysis.

Figure 1
Figure 1. Waters Synapt G2 HDMS instrument and an example of a three-dimensional data set including mass-to-charge ratio, ion mobility drift time, and ion intensity.

For more information, please visit the Dodds Research Group Homepage.

Selected Publications

(1) Energy-resolved collision-induced dissociation pathways of model N-linked glycopeptides: implications for capturing glycan connectivity and peptide sequence in a single experiment, V. Kolli and E. D. Dodds, Analyst 139: 2144-2153 (2014)

(2) Carbohydrate and glycoconjugate analysis by ion mobility mass spectrometry: opportunities and challenges, Y. Huang, A. S. Gelb, and E. D. Dodds, Current Metabolomics 1: 291-305 (2013)

(3) Ion mobility studies of carbohydrates as group I adducts: isomer specific collisional cross section dependence on metal ion radius, Y. Huang and E. D. Dodds, Analytical Chemistry 85: 9728-9735 (2013)

(4) A classifier based on accurate mass measurements to aid large-scale, unbiased glycoproteomics, J. W. Froehlich, E. D. Dodds, M. Wilhelm, O. Serang, J. A. Steen, and R. S. Lee, Molecular & Cellular Proteomics 12: 1017-1025 (2013)

(5) Gas-phase dissociation of glycosylated peptide ions, E. D. Dodds, Mass Spectrometry Reviews 31: 666-682 (2012)

Complete list of publications